Sensitivity of changes in chronic graft-versus-host disease activity to changes in patient-reported quality of life: results from the Chronic Graft-versus-Host Disease Consortium.

Publication Type:

Journal Article


Haematologica, Volume 96, Issue 10, p.1528-35 (2011)


2011, Adult, Aged, Center-Authored Paper, Chronic Disease, Clinical Research Division, Cohort Studies, Consortium Authored Paper, Diagnostic Self Evaluation, Female, Graft vs Host Disease, hematopoietic stem cell transplantation, Humans, Male, Middle Aged, Outcome Assessment (Health Care), Quality of Life, Research Trials Office Core Facility - Biostatistics Service, Severity of Illness Index, Shared Resources, Young Adult


The 2005 National Institute of Health Chronic Graft-versus-Host Disease Consensus Conference recommended collection of patient-reported outcomes in clinical trials on chronic graft-versus-host disease. We assessed whether changes in chronic graft-versus-host disease severity, determined using National Institute of Health criteria, clinicians' assessment or patients' self-evaluation, correlated with patient-reported quality of life as measured by the Short Form-36 and Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT) instruments.