Safety and immunogenicity of a replication-incompetent adenovirus type 5 HIV-1 clade B gag/pol/nef vaccine in healthy adults.

Publication Type:

Journal Article

Source:

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Volume 46, Issue 11, p.1769-81 (2008)

Keywords:

2008, Adenoviridae, Adult, AIDS Vaccines, Female, Fusion Proteins, gag-pol, Genes, gag, Genes, pol, HIV Antibodies, HIV Infections, HIV-1, Humans, Male, Safety, Vaccine and Infectious Disease Institute, Vaccines, DNA

Abstract:

The safety and immunogenicity of the MRK adenovirus type 5 human immunodeficiency virus type 1 clade B gag/pol/nef vaccine, a replication-incompetent adenovirus type 5-vectored vaccine designed to elicit cell-mediated immunity against conserved human immunodeficiency virus proteins, was assessed in a phase 1 trial.