The role of KRAS rs61764370 in invasive epithelial ovarian cancer: implications for clinical testing.

Publication Type:

Journal Article

Authors:

Pharoah, Paul D P; Palmieri, Rachel T; Ramus, Susan J; Gayther, Simon A; Andrulis, Irene L; Anton-Culver, Hoda; Antonenkova, Natalia; Antoniou, Antonis C; Goldgar, David; Beattie, Mary S; Beckmann, Matthias W; Birrer, Michael J; Bogdanova, Natalia; Bolton, Kelly L; Brewster, Wendy; Brooks-Wilson, Angela; Brown, Robert; Butzow, Ralf; Caldes, Trinidad; Caligo, Maria Adelaide; Campbell, Ian; Chang-Claude, Jenny; Chen, Y Ann; Cook, Linda S; Couch, Fergus J; Cramer, Daniel W; Cunningham, Julie M; Despierre, Evelyn; Doherty, Jennifer A; Dörk, Thilo; Dürst, Matthias; Eccles, Diana M; Ekici, Arif B; Easton, Douglas; Fasching, Peter A; Defazio, Anna; Fenstermacher, David A; Flanagan, James M; Fridley, Brooke L; Friedman, Eitan; Gao, Bo; Sinilnikova, Olga; Gentry-Maharaj, Aleksandra; Godwin, Andrew K; Goode, Ellen L; Goodman, Marc T; Gross, Jenny; Hansen, Thomas V O; Harnett, Paul; Rookus, Matti; Heikkinen, Tuomas; Hein, Rebecca; Høgdall, Claus; Høgdall, Estrid; Iversen, Edwin S; Jakubowska, Anna; Johnatty, Sharon E; Karlan, Beth Y; Kauff, Noah D; Kaye, Stanley B; Chenevix-Trench, Georgia; Kelemen, Linda E; Kiemeney, Lambertus A; Kjaer, Susanne Krüger; Lambrechts, Diether; Lapolla, James P; Lázaro, Conxi; Le, Nhu D; Leminen, Arto; Leunen, Karin; Levine, Douglas A; Lu, Yi; Lundvall, Lene; Macgregor, Stuart; Marees, Tamara; Massuger, Leon F; McLaughlin, John R; Menon, Usha; Montagna, Marco; Moysich, Kirsten B; Narod, Steven A; Nathanson, Katherine L; Nedergaard, Lotte; Ness, Roberta B; Nevanlinna, Heli; Nickels, Stefan; Osorio, Ana; Paul, Jim; Pearce, Celeste Leigh; Phelan, Catherine M; Pike, Malcolm C; Radice, Paolo; Rossing, Mary Anne; Schildkraut, Joellen M; Sellers, Thomas A; Singer, Christian F; Song, Honglin; Stram, Daniel O; Sutphen, Rebecca; Lindblom, Annika; Terry, Kathryn L; Tsai, Ya-Yu; van Altena, Anne M; Vergote, Ignace; Vierkant, Robert A; Vitonis, Allison F; Walsh, Christine; Wang-Gohrke, Shan; Wappenschmidt, Barbara; Wu, Anna H; Ziogas, Argyrios; Berchuck, Andrew; Risch, Harvey A

Source:

Clinical cancer research : an official journal of the American Association for Cancer Research, Volume 17, Issue 11, p.3742-50 (2011)

Keywords:

2011, 3' Untranslated Regions, Center-Authored Paper, Disease-Free Survival, Early Detection of Cancer, Female, Genes, BRCA1, Genetic Predisposition to Disease, Genotype, Humans, MICRORNAS, Neoplasm Invasiveness, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Polymorphism, Single Nucleotide, Proto-Oncogene Proteins, Public Health Sciences Division, ras Proteins, RISK

Abstract:

An assay for the single-nucleotide polymorphism (SNP), rs61764370, has recently been commercially marketed as a clinical test to aid ovarian cancer risk evaluation in women with family histories of the disease. rs67164370 is in a 3'-UTR miRNA binding site of the KRAS oncogene and is a candidate for epithelial ovarian cancer (EOC) susceptibility. However, only one published article, analyzing fewer than 1,000 subjects in total, has examined this association.