RNA interference: the new somatic cell genetics?

Publication Type:

Journal Article


Cancer cell, Volume 2, Issue 1, p.17-23 (2002)


Animals, Base Sequence, Cells, Cultured, Cytogenetic Analysis, DNA-Directed RNA Polymerases, gene expression, Gene Silencing, Humans, Models, Genetic, RNA, Double-Stranded, RNA, Small Interfering, Viral Proteins


RNAi is evolving into a powerful tool for manipulating gene expression in mammalian cells with potential utility for investigating gene function, for high-throughput, function-based genetic screens and potentially for development as a therapeutic tool.