Risks of Lynch syndrome cancers for MSH6 mutation carriers.

Publication Type:

Journal Article


Journal of the National Cancer Institute, Volume 102, Issue 3, p.193-201 (2010)


2010, Adult, Age Distribution, Age Factors, Aged, Aged, 80 and over, Australia, Canada, Center-Authored Paper, Colorectal Neoplasms, Hereditary Nonpolyposis, DNA-Binding Proteins, Endometrial Neoplasms, Europe, Female, Gene Deletion, Germ-Line Mutation, Heterozygote, Humans, Incidence, Male, Middle Aged, Mutagenesis, Insertional, Neoplasms, New Zealand, Public Health Sciences Division, Registries, Risk Assessment, Risk Factors, Sex Distribution, Sex Factors, United States


Germline mutations in MSH6 account for 10%-20% of Lynch syndrome colorectal cancers caused by hereditary DNA mismatch repair gene mutations. Because there have been only a few studies of mutation carriers, their cancer risks are uncertain.