Risks of Lynch syndrome cancers for MSH6 mutation carriers.

Publication Type:

Journal Article

Source:

Journal of the National Cancer Institute, Volume 102, Issue 3, p.193-201 (2010)

Keywords:

2010, Adult, Age Distribution, Age Factors, Aged, Aged, 80 and over, Australia, Canada, Center-Authored Paper, Colorectal Neoplasms, Hereditary Nonpolyposis, DNA-Binding Proteins, Endometrial Neoplasms, Europe, Female, Gene Deletion, Germ-Line Mutation, Heterozygote, Humans, Incidence, Male, Middle Aged, Mutagenesis, Insertional, Neoplasms, New Zealand, Public Health Sciences Division, Registries, Risk Assessment, Risk Factors, Sex Distribution, Sex Factors, United States

Abstract:

Germline mutations in MSH6 account for 10%-20% of Lynch syndrome colorectal cancers caused by hereditary DNA mismatch repair gene mutations. Because there have been only a few studies of mutation carriers, their cancer risks are uncertain.