Risk factors for end stage renal disease in non-WT1-syndromic Wilms tumor.

Publication Type:

Journal Article

Authors:

Lange, Jane; Peterson, Susan M; Takashima, Janice R; Grigoriev, Yevgeny; Ritchey, Michael L; Shamberger, Robert C; Beckwith, J Bruce; Perlman, Elizabeth; Green, Daniel M; Breslow, Norman E

Source:

The Journal of urology, Volume 186, Issue 2, p.378-86 (2011)

Keywords:

2011, Center-Authored Paper, Child, Preschool, Consortium Authored Paper, Genes, Wilms Tumor, Humans, Infant, Kidney Failure, Chronic, Kidney Neoplasms, Public Health Sciences Division, Risk Factors, Wilms Tumor

Abstract:

We assessed risk factors for end stage renal disease in patients with Wilms tumor without known WT1 related syndromes. We hypothesized that patients with characteristics suggestive of a WT1 etiology (early onset, stromal predominant histology, intralobar nephrogenic rests) would have a higher risk of end stage renal disease due to chronic renal failure. We predicted a high risk of end stage renal disease due to progressive bilateral Wilms tumor in patients with metachronous bilateral disease.