Rigorous and thorough bioinformatic analyses of olfactory receptor promoters confirm enrichment of O/E and homeodomain binding sites but reveal no new common motifs.

Publication Type:

Journal Article

Source:

BMC genomics, Volume 12, p.561 (2011)

Keywords:

2011, Algorithms, Animals, Binding Sites, Center-Authored Paper, Clinical Research Division, Computational Biology, Conserved Sequence, Databases, Genetic, Gene Expression Regulation, Homeodomain Proteins, Human Biology Division, Jan 12, MICE, Promoter Regions, Genetic, Receptors, Odorant, Sequence Alignment, Sequence Analysis, DNA, TATA Box, TRANSCRIPTION FACTORS

Abstract:

Mammalian olfactory receptors (ORs) are subject to a remarkable but poorly understood regime of transcriptional regulation, whereby individual olfactory neurons each express only one allele of a single member of the large OR gene family.