ret/PTC activation is not associated with individual radiation dose estimates in a pilot study of neoplastic thyroid nodules arising in Russian children and adults exposed to Chernobyl fallout.

Publication Type:

Journal Article


Thyroid : official journal of the American Thyroid Association, Volume 18, Issue 8, p.839-46 (2008)


2008, Adult, Chernobyl Nuclear Accident, Dose-Response Relationship, Radiation, Humans, Neoplasms, Radiation-Induced, Oncogene Proteins, Fusion, Pilot Projects, Protein-Tyrosine Kinases, Proto-Oncogene Proteins c-ret, Public Health Sciences Division, Thyroid Neoplasms, Thyroid Nodule, Ukraine


Ionizing radiation is the strongest risk factor known for the development of thyroid neoplasia. While previous studies have demonstrated a high prevalence of ret/papillary thyroid cancer (PTC) activation in cohorts of patients developing thyroid nodules after childhood exposure to ionizing radiation, no study has directly compared ret/PTC activation with individual estimates of radiation dose to the thyroid. This study combines individual thyroid dosimetry data with molecular analysis of surgically removed thyroid nodules in order to determine if ret/PTC activation in thyroid nodules is associated with increasing estimated radiation dose from Chernobyl.