Reproductive history and oral contraceptive use in relation to risk of triple-negative breast cancer.

Publication Type:

Journal Article

Source:

Journal of the National Cancer Institute, Volume 103, Issue 6, p.470-7 (2011)

Keywords:

2011, African Americans, Age Factors, Aged, Breast Feeding, Breast Neoplasms, Contraceptives, Oral, European Continental Ancestry Group, Female, Humans, Mammography, Menarche, Menopause, Middle Aged, Parity, Proportional Hazards Models, Public Health Sciences Division, Receptor, erbB-2, Receptors, Estrogen, Receptors, Progesterone, Reproductive History, Risk Assessment, Risk Factors, Tumor Markers, Biological, United States, Women's Health

Abstract:

Triple-negative (ie, estrogen receptor [ER], progesterone receptor, and HER2 negative) breast cancer occurs disproportionately among African American women compared with white women and is associated with a worse prognosis than ER-positive (ER+) breast cancer. Hormonally mediated risk factors may be differentially related to risk of triple-negative and ER+ breast cancers.