Reproductive factors and risk of contralateral breast cancer by BRCA1 and BRCA2 mutation status: results from the WECARE study.

Publication Type:

Journal Article

Source:

Cancer causes & control : CCC, Volume 21, Issue 6, p.839-46 (2010)

Keywords:

2010, BRCA2 Protein, Breast Neoplasms, Case-Control Studies, Center-Authored Paper, Female, Genes, BRCA2, Humans, Logistic Models, Menarche, Menopause, Mutation, Neoplasms, Parity, PREGNANCY, Public Health Sciences Division, Reproductive History, RISK, Risk Factors

Abstract:

Reproductive factors, such as early age at menarche, late age at menopause, and nulliparity are known risk factors for breast cancer. Previously, we reported these factors to be associated with risk of developing contralateral breast cancer (CBC). In this study, we evaluated the association between these factors and CBC risk among BRCA1 and BRCA2 (BRCA1/2) mutation carriers and non-carriers.