Reproductive and hormonal risk factors for postmenopausal luminal, HER-2-overexpressing, and triple-negative breast cancer.

Publication Type:

Journal Article


Cancer, Volume 113, Issue 7, p.1521-6 (2008)


2008, Aged, Breast Feeding, Breast Neoplasms, Case-Control Studies, Center-Authored Paper, Epidemiology Core Facility, Female, Hormone Replacement Therapy, Human Biology Division, Humans, Middle Aged, Neoplasms, Hormone-Dependent, Odds Ratio, Parity, Postmenopause, PREGNANCY, Public Health Sciences Division, Receptor, erbB-2, Reproductive History, Risk Factors, Shared Resources


Molecular profiling studies have identified subtypes of breast cancer that can be approximately classified by estrogen receptor (ER), progesterone receptor (PR), and HER-2/neu (HER-2) expression. These molecular subtypes are prognostically significant, but to the authors' knowledge, differences in their etiologic profiles have not been established. Reproductive factors may plausibly be differentially correlated with the risk of different breast cancer subtypes because these factors are presumed to impact exposure to endogenous sex hormones.