Renal thrombotic microangiopathy after hematopoietic cell transplant: role of GVHD in pathogenesis.

Publication Type:

Journal Article


Clinical journal of the American Society of Nephrology : CJASN, Volume 4, Issue 2, p.345-53 (2009)


2009, Adenoviridae Infections, Adolescent, Adult, Aged, Autopsy, Child, Child, Preschool, Clinical Research Division, Female, Graft vs Host Disease, hematopoietic stem cell transplantation, Humans, Infant, Kidney, Kidney Diseases, Logistic Models, Male, Middle Aged, Odds Ratio, Prevalence, Radiation Dosage, Risk Assessment, Risk Factors, Severity of Illness Index, Sex Factors, Thrombocytopenia, Thrombosis, Young Adult


Thrombotic microangiopathy (TMA) is a known complication of hematopoietic cell transplantation (HCT). The etiology and diagnosis of TMA in this patient population is often difficult because thrombocytopenia, microangiopathic hemolytic anemia, and kidney injury occur frequently in HCT recipients, and are the result of a variety of insults.