Relationship between interferon regulatory factor 4 genetic polymorphisms, measures of sun sensitivity and risk for non-Hodgkin lymphoma.

Publication Type:

Journal Article

Source:

Cancer causes & control : CCC, Volume 20, Issue 8, p.1291-302 (2009)

Keywords:

2009, Adult, Aged, Aged, 80 and over, Center-Authored Paper, Environmental Exposure, Female, Genetic Predisposition to Disease, Humans, Interferon Regulatory Factors, Lymphoma, Non-Hodgkin, Male, Middle Aged, Polymorphism, Single Nucleotide, Public Health Sciences Division, Radiation Tolerance, Risk Factors, Skin Pigmentation, Sunlight, Young Adult

Abstract:

Sun exposure and sensitivity, including pigmentation, are associated with risk for non-Hodgkin lymphoma (NHL). One variant in the immune regulatory factor 4 (IRF4) gene (rs12203592) is associated with pigmentation, and a different IRF4 variant (rs12211228) is associated with NHL risk. We evaluated the independent roles of these IRF4 polymorphisms and sun sensitivity in mediating NHL risk and explored whether they are confounded or modified by each other.