Regulation of prokaryotic gene expression by eukaryotic-like enzymes.

Publication Type:

Journal Article


Current opinion in microbiology, Volume 15, Issue 2, p.125-31 (2012)


Animals, Bacteria, Bacterial Proteins, Consortium Authored Paper, Gene Expression Regulation, Bacterial, Humans, Phosphoprotein Phosphatases, Protein Processing, Post-Translational, Protein-Serine-Threonine Kinases, Proteomics Core Facility, Shared Resources, Signal Transduction


A growing body of evidence indicates that serine/threonine kinases (STKs) and phosphatases (STPs) regulate gene expression in prokaryotic organisms. As prokaryotic STKs and STPs are not DNA binding proteins, regulation of gene expression is accomplished through post-translational modification of their targets. These include two-component response regulators, DNA binding proteins and proteins that mediate transcription and translation. This review summarizes our current understanding of how STKs and STPs mediate gene expression in prokaryotes. Further studies to identify environmental signals that trigger the signaling cascade and elucidation of mechanisms that regulate crosstalk between eukaryotic-like signaling enzymes, two-component systems, and components of the transcriptional and translational machinery will facilitate a greater understanding of prokaryotic gene regulation.