Reduction by granulocyte colony-stimulating factor of fever and neutropenia induced by chemotherapy in patients with small-cell lung cancer.

Publication Type:

Journal Article


The New England journal of medicine, Volume 325, Issue 3, p.164-70 (1991)


Antineoplastic Combined Chemotherapy Protocols, Carcinoma, Small Cell, Combined Modality Therapy, Cyclophosphamide, Double-Blind Method, Doxorubicin, Drug Administration Schedule, Etoposide, Fever, Granulocyte Colony-Stimulating Factor, Humans, Infection Control, Length of Stay, Lung Neoplasms, NEUTROPENIA, Recombinant Proteins, Survival Rate


Neutropenia and infection are major dose-limiting side effects of chemotherapy. Previous studies have suggested that recombinant methionyl granulocyte colony-stimulating factor (G-CSF) can reduce chemotherapy-related neutropenia in patients with cancer. We conducted a randomized clinical trial to test this hypothesis and the clinical implications.