Reduced adipogenic gene expression in thigh adipose tissue precedes human immunodeficiency virus-associated lipoatrophy.

Publication Type:

Journal Article

Authors:

Kratz, Mario; Purnell, Jonathan Q; Breen, Patricia A; Thomas, Katherine K; Utzschneider, Kristina M; Carr, Darcy B; Kahn, Steven E; Hughes, James P; Rutledge, Elizabeth A; Van Yserloo, Brian; Yukawa, Michi; Weigle, David S

Source:

The Journal of clinical endocrinology and metabolism, Volume 93, Issue 3, p.959-66 (2008)

Keywords:

11-beta-Hydroxysteroid Dehydrogenases, 2008, Adipogenesis, Adipose Tissue, Antiretroviral Therapy, Highly Active, CCAAT-Enhancer-Binding Protein-alpha, CCAAT-Enhancer-Binding Protein-beta, Center-Authored Paper, Cholesterol, HDL, Gene Expression Regulation, HIV-Associated Lipodystrophy Syndrome, Humans, Insulin Resistance, Longitudinal Studies, Prospective Studies, Public Health Sciences Division, Thigh, Triglycerides

Abstract:

The expression of adipogenic genes in sc adipose tissue has been reported to be lower among patients with HIV-associated lipoatrophy than HIV-uninfected controls. It is unclear whether this is a result or cause of lipoatrophy.