Reduced adipogenic gene expression in thigh adipose tissue precedes human immunodeficiency virus-associated lipoatrophy.

Publication Type:

Journal Article


The Journal of clinical endocrinology and metabolism, Volume 93, Issue 3, p.959-66 (2008)


11-beta-Hydroxysteroid Dehydrogenases, 2008, Adipogenesis, Adipose Tissue, Antiretroviral Therapy, Highly Active, CCAAT-Enhancer-Binding Protein-alpha, CCAAT-Enhancer-Binding Protein-beta, Center-Authored Paper, Cholesterol, HDL, Gene Expression Regulation, HIV-Associated Lipodystrophy Syndrome, Humans, Insulin Resistance, Longitudinal Studies, Prospective Studies, Public Health Sciences Division, Thigh, Triglycerides


The expression of adipogenic genes in sc adipose tissue has been reported to be lower among patients with HIV-associated lipoatrophy than HIV-uninfected controls. It is unclear whether this is a result or cause of lipoatrophy.