Recombinant structures expand and contract inter and intragenic diversification at the KIR locus.

Publication Type:

Journal Article

Source:

BMC genomics, Volume 14, p.89 (2013)

Keywords:

2013, Clinical Research Division, March 2013

Abstract:

The human KIR genes are arranged in at least six major gene-content haplotypes, all of which are combinations of four centromeric and two telomeric motifs. Several less frequent or minor haplotypes also exist, including insertions, deletions, and hybridization of KIR genes derived from the major haplotypes. These haplotype structures and their concomitant linkage disequilibrium among KIR genes suggest that more meaningful correlative data from studies of KIR genetics and complex disease may be achieved by measuring haplotypes of the KIR region in total.