Recombinant Listeria monocytogenes expressing an immunodominant peptide fails to protect after intravaginal challenge with herpes simplex virus-2.

Publication Type:

Journal Article

Source:

Archives of virology, Volume 153, Issue 6, p.1165-9 (2008)

Keywords:

2008, Animals, CD8-Positive T-Lymphocytes, Female, Herpes Genitalis, Herpes Simplex Virus Vaccines, Herpesvirus 2, Human, Immunodominant Epitopes, Injections, Intravenous, Listeria monocytogenes, MICE, Mice, Inbred C57BL, Recombination, Genetic, Simplexvirus, T-Cell Antigen Receptor Specificity, Vaccination, Vaccine and Infectious Disease Institute, Vaccines, Synthetic, Viral Envelope Proteins

Abstract:

Recombinant Listeria monocytogenes expressing a type-common herpes simplex virus (HSV) gB-peptide was shown previously to protect against footpad inoculation with HSV-1. We tested this construct for protection against vaginal challenge with HSV-2. Primed mice demonstrated strong recall responses, had modest reductions in HSV-2 DNA in vaginal mucosa, but were not protected from disease.