Rapidly cleared episodes of herpes simplex virus reactivation in immunocompetent adults.

Publication Type:

Journal Article


The Journal of infectious diseases, Volume 198, Issue 8, p.1141-9 (2008)


2008, Adult, Aged, Antibodies, Viral, Female, Genitalia, Herpes Genitalis, Herpes Simplex, Herpesvirus 1, Human, Herpesvirus 2, Human, Humans, Immunocompetence, Male, Middle Aged, Mouth Mucosa, Time Factors, Vaccine and Infectious Disease Institute, Virus Activation, Virus Shedding


Herpes simplex virus (HSV) remains latent in nerve root ganglia of infected persons and is thought to reactivate several times yearly. Recent in situ data show the localization of HSV-specific CD8(+) T cells at the dermal epidermal junction next to peripheral sensory nerve endings, suggesting that viral reactivation may occur more frequently than previously appreciated.