Rapidly cleared episodes of herpes simplex virus reactivation in immunocompetent adults.

Publication Type:

Journal Article

Source:

The Journal of infectious diseases, Volume 198, Issue 8, p.1141-9 (2008)

Keywords:

2008, Adult, Aged, Antibodies, Viral, Female, Genitalia, Herpes Genitalis, Herpes Simplex, Herpesvirus 1, Human, Herpesvirus 2, Human, Humans, Immunocompetence, Male, Middle Aged, Mouth Mucosa, Time Factors, Vaccine and Infectious Disease Institute, Virus Activation, Virus Shedding

Abstract:

Herpes simplex virus (HSV) remains latent in nerve root ganglia of infected persons and is thought to reactivate several times yearly. Recent in situ data show the localization of HSV-specific CD8(+) T cells at the dermal epidermal junction next to peripheral sensory nerve endings, suggesting that viral reactivation may occur more frequently than previously appreciated.