Rapid Induction of Androgen Receptor Splice Variants by Androgen Deprivation in Prostate Cancer.

Publication Type:

Journal Article

Source:

Clinical cancer research : an official journal of the American Association for Cancer Research (2014)

Keywords:

2014, Center-Authored Paper, Clinical Research Division, February 2014, Human Biology Division, Public Health Sciences Division

Abstract:

Mechanisms mediating androgen receptor (AR) reactivation in prostate cancer (PCa) that progresses after castration (castration-resistant prostate cancer, CRPC) and subsequent treatment with abiraterone (CYP17A1 inhibitor that further suppresses androgen synthesis) remain unclear.