Randomized trial of glucosamine and chondroitin supplementation on inflammation and oxidative stress biomarkers and plasma proteomics profiles in healthy humans.

Publication Type:

Journal Article

Source:

PloS one, Volume 10, Issue 2, p.e0117534 (2015)

Keywords:

Nutrition Assessment Core Facility, Prevention Center Core Facility, Specimen Processing Facility

Abstract:

Glucosamine and chondroitin are popular non-vitamin dietary supplements used for osteoarthritis. Long-term use is associated with lower incidence of colorectal and lung cancers and with lower mortality; however, the mechanism underlying these observations is unknown. In vitro and animal studies show that glucosamine and chondroitin inhibit NF-kB, a central mediator of inflammation, but no definitive trials have been done in healthy humans.