Radiation exposure, the ATM Gene, and contralateral breast cancer in the women's environmental cancer and radiation epidemiology study.

Publication Type:

Journal Article

Source:

Journal of the National Cancer Institute, Volume 102, Issue 7, p.475-83 (2010)

Keywords:

2010, Adult, Age Factors, Aged, Breast Neoplasms, Case-Control Studies, Cell Cycle Proteins, Center-Authored Paper, DNA Damage, DNA-Binding Proteins, Environmental Exposure, Female, Genetic Predisposition to Disease, Humans, International Cooperation, Middle Aged, Mutation, Missense, Neoplasms, Radiation-Induced, Neoplasms, Second Primary, Odds Ratio, Protein-Serine-Threonine Kinases, Public Health Sciences Division, Radiation Injuries, Risk Assessment, Risk Factors, Time Factors, Tumor Suppressor Proteins

Abstract:

Ionizing radiation is a known mutagen and an established breast carcinogen. The ATM gene is a key regulator of cellular responses to the DNA damage induced by ionizing radiation. We investigated whether genetic variants in ATM play a clinically significant role in radiation-induced contralateral breast cancer in women.