Proteome and transcriptome profiles of a Her2/Neu-driven mouse model of breast cancer.

Publication Type:

Journal Article

Source:

Proteomics. Clinical applications, Volume 5, Issue 3-4, p.179-88 (2011)

Keywords:

2011, Animals, Breast Neoplasms, Center-Authored Paper, Clinical Research Division, Databases, Protein, Disease Models, Animal, Gene Expression Profiling, Genomics Core Facility, Human Biology Division, MICE, Mice, Transgenic, Proteome, PROTEOMICS, Public Health Sciences Division, Receptor, erbB-2, Shared Resources, Tandem Mass Spectrometry, Transcription, Genetic

Abstract:

We generated extensive transcriptional and proteomic profiles from a Her2-driven mouse model of breast cancer that closely recapitulates human breast cancer. This report makes these data publicly available in raw and processed forms, as a resource to the community. Importantly, we previously made biospecimens from this same mouse model freely available through a sample repository, so researchers can obtain samples to test biological hypotheses without the need of breeding animals and collecting biospecimens.