Prostate cancer-associated gene expression alterations determined from needle biopsies.

Publication Type:

Journal Article

Source:

Clinical cancer research : an official journal of the American Association for Cancer Research, Volume 15, Issue 9, p.3135-42 (2009)

Keywords:

2009, Biopsy, Needle, Center-Authored Paper, Clinical Research Division, Gene Expression Profiling, Genomics Core Facility, Human Biology Division, Humans, Lasers, Male, microdissection, Oligonucleotide Array Sequence Analysis, Prostatic Hyperplasia, Prostatic Neoplasms, Reverse Transcriptase Polymerase Chain Reaction, RNA, Messenger, Shared Resources, Tumor Markers, Biological

Abstract:

To accurately identify gene expression alterations that differentiate neoplastic from normal prostate epithelium using an approach that avoids contamination by unwanted cellular components and is not compromised by acute gene expression changes associated with tumor devascularization and resulting ischemia.