Prospective study of sequential reduction in immunosuppression, interferon alpha-2B, and chemotherapy for posttransplantation lymphoproliferative disorder.
Publication Type:
Journal ArticleSource:
Transplantation, Volume 86, Issue 2, p.215-22 (2008)Keywords:
2008, Acyclovir, Adult, Aged, Antineoplastic Agents, Cyclosporine, Female, Heart Transplantation, Humans, Immunosuppressive Agents, Interferon Alfa-2b, Kidney Transplantation, Lymphoproliferative Disorders, Male, Middle Aged, Postoperative Complications, Public Health Sciences Division, Remission Induction, TacrolimusAbstract:
Several interventions can cure posttransplant lymphoproliferative disease (PTLD); a sequential approach is usual, starting with reduction in immunosuppressives (RI). The efficacy of RI remains poorly defined, particularly in adults. We assessed an algorithm starting with a defined course of RI in all patients, escalating to interferon (IFN) alpha2b, and finally to chemotherapy, in a prospective multicenter phase II study of adult solid organ transplant recipients. The design predated rituximab.
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