A prospective, multicenter, National Cancer Institute Early Detection Research Network study of [-2]proPSA: improving prostate cancer detection and correlating with cancer aggressiveness.

Publication Type:

Journal Article

Source:

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Volume 19, Issue 5, p.1193-200 (2010)

Keywords:

2010, Adult, Aged, Aged, 80 and over, Center-Authored Paper, Humans, Male, Middle Aged, National Cancer Institute (U.S.), Neoplasm Staging, Prospective Studies, Prostate-Specific Antigen, Prostatic Neoplasms, Public Health Sciences Division, ROC Curve, United States

Abstract:

The free prostate-specific antigen (PSA) isoform, [-2]proPSA, has been shown to be associated with prostate cancer. The study objective was to characterize the clinical utility of serum [-2]proPSA for prostate cancer detection and assess its association with aggressive disease.