Prophylactic colony-stimulating factors in children receiving myelosuppressive chemotherapy: a meta-analysis of randomized controlled trials.

Publication Type:

Journal Article


Cancer treatment reviews, Volume 32, Issue 4, p.289-303 (2006)


Anti-Bacterial Agents, Antineoplastic Agents, Bone Marrow, Chemoprevention, Child, Colony-Stimulating Factors, Granulocyte Colony-Stimulating Factor, Granulocyte-Macrophage Colony-Stimulating Factor, Hospitalization, Humans, NEUTROPENIA, Randomized Controlled Trials as Topic, Risk Factors, Time Factors


The colony-stimulating factors (CSFs) are widely utilized to prevent neutropenic complications in both adults and children, but randomized controlled trials in the pediatric setting have reported varied results. A systematic review of the literature and meta-analysis were conducted to definitively assess the impact of prophylactic CSFs on the risk of febrile neutropenia (FN) in pediatric oncology patients.