Prognostic value and functional consequences of cell cycle inhibitor p27Kip1 loss in medulloblastoma.

Publication Type:

Journal Article

Authors:

Hatton, Beryl A; Ellison, David W; Gajjar, Amar; Kool, Marcel; Fero, Matthew; Olson, James M

Source:

Biomarker research, Volume 1, Issue 1, p.14 (2013)

Keywords:

2013, Center-Authored Paper, Clinical Research Division, Comp Med Small Animal, Comparative Medicine Core Facility, December 2013, Scientific Imaging Core Facility

Abstract:

The cyclin-dependent kinase inhibitor p27Kip1 functions during normal cerebellar development and has demonstrated tumor suppressor functions in mouse models of medulloblastoma. Because P27 loss is associated with increased proliferation, we assessed whether P27 absence in surgical medulloblastoma specimens correlated with response to therapy in pediatric patients enrolled in two large studies. Additionally, we examined the functional consequence of p27Kip1 loss in the SmoA1 medulloblastoma model to distinguish whether p27Kip1 reduces tumor initiation or slows tumor progression.