Prognostic role of ERCC1 in advanced non-small-cell lung cancer: a systematic review and meta-analysis.

Publication Type:

Journal Article


Clinical lung cancer, Volume 12, Issue 6, p.393-401 (2011)


Carcinoma, Non-Small-Cell Lung, DNA-Binding Proteins, Endonucleases, Humans, Lung Neoplasms, Meta-Analysis as Topic, Prognosis, Risk Factors, Survival Rate


Small observational studies have demonstrated an association between high ERCC1 expression level and poor prognosis in advanced NSCLC treated with platinum-based chemotherapy. This meta-analysis presents pooled estimates of association from 11 studies. High ERCC1 patients had lower response rates and higher risk of death relative to low ERCC1 patients. These results support the prognostic significance of ERCC1 expression level in advanced NSCLC.