The prognostic effect of high diagnostic WT1 gene expression in pediatric AML depends on WT1 SNP rs16754 status: Report from the Children's Oncology Group.

Publication Type:

Journal Article

Authors:

Ho, Phoenix A; Alonzo, Todd A; Gerbing, Robert B; Kuhn, Julia; Pollard, Jessica A; Hirsch, Betsy; Raimondi, Susana C; Gamis, Alan S; Meshinchi, Soheil

Source:

Pediatric blood & cancer (2013)

Keywords:

2013, Clinical Research Division, September 2013

Abstract:

WT1 is aberrantly over-expressed in most cases of AML. We recently demonstrated that WT1 SNP rs16754 correlates with favorable outcome and high diagnostic WT1 expression in childhood AML. We examined the clinical correlates of diagnostic WT1 expression within a contemporary COG trial and determined whether its prognostic impact differs between SNP+ and SNP- patients.