Prevalence of chromosomally integrated human herpesvirus 6 in patients with human herpesvirus 6-central nervous system dysfunction.

Publication Type:

Journal Article

Source:

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, Volume 21, Issue 2, p.371-3 (2015)

Keywords:

Central Nervous System, Chromosomes, Human, DNA, Viral, Encephalitis, Viral, Experimental Histopathology Core Facility, Genomics Core Facility, hematopoietic stem cell transplantation, Herpesvirus 6, Human, Humans, Molecular Typing, Phylogeny, Roseolovirus Infections, Transplantation, Homologous, Virus Activation, Virus Integration

Abstract:

We identified 37 hematopoietic cell transplantation recipients with human herpesvirus 6 (HHV-6) central nervous system dysfunction and tested donor-recipient pairs for chromosomally integrated HHV-6 (ciHHV-6). One patient had ciHHV-6A with possible HHV-6A reactivation and encephalitis. There was no ciHHV-6 enrichment in this group, but larger studies are needed to determine if patients with ciHHV-6 are at increased risk for HHV-6-associated diseases or other complications.