Preliminary evaluation of factors associated with premature trial closure and feasibility of accrual benchmarks in phase III oncology trials.

Publication Type:

Journal Article

Source:

Clinical trials (London, England), Volume 7, Issue 4, p.312-21 (2010)

Keywords:

2010, Benchmarking, Center-Authored Paper, Clinical Trials, Phase III as Topic, Humans, Neoplasms, Patient Selection, Pilot Projects, Public Health Sciences Division, Research Design

Abstract:

A major challenge for randomized phase III oncology trials is the frequent low rates of patient enrollment, resulting in high rates of premature closure due to insufficient accrual.