The potential of genes and other markers to inform about risk.

Publication Type:

Journal Article


Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Volume 19, Issue 3, p.655-65 (2010)


2010, Biological Markers, Center-Authored Paper, Genetic Predisposition to Disease, Genetic Testing, Humans, Models, Statistical, Odds Ratio, Predictive Value of Tests, Public Health Sciences Division, RISK, Risk Assessment, ROC Curve


Advances in biotechnology have raised expectations that biomarkers, including genetic profiles, will yield information to accurately predict outcomes for individuals. However, results to date have been disappointing. In addition, statistical methods to quantify the predictive information in markers have not been standardized.