Population-based study of the risk of second primary contralateral breast cancer associated with carrying a mutation in BRCA1 or BRCA2.

Publication Type:

Journal Article

Source:

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Volume 28, Issue 14, p.2404-10 (2010)

Keywords:

2010, Adult, Age Factors, Apoptosis Regulatory Proteins, BRCA1 Protein, BRCA2 Protein, Breast Neoplasms, Case-Control Studies, Center-Authored Paper, Denmark, DNA Mutational Analysis, Female, Genetic Predisposition to Disease, Humans, Logistic Models, Middle Aged, Mutation, Neoplasm Recurrence, Local, Population Surveillance, Public Health Sciences Division, Risk Assessment, Risk Factors, SEER Program, Time Factors, Treatment Outcome, United States

Abstract:

Women with breast cancer diagnosed early in life comprise a substantial portion of those tested for BRCA1/BRCA2 mutations; however, little information is available on the subsequent risks of contralateral breast cancer in mutation carriers. This study assessed the risk of subsequent contralateral breast cancer associated with carrying a BRCA1 or BRCA2 mutation.