A population-based case-control study of genetic variation in cytokine genes associated with risk of cervical and vulvar cancers.

Publication Type:

Journal Article

Source:

Gynecologic oncology, Volume 139, Issue 1, p.90-6 (2015)

Keywords:

Epidemiology Core Facility, Genomics Core Facility, Specimen Processing Core Facility

Abstract:

Persistent infection with oncogenic human papillomavirus (HPV) is known to be the necessary cause of cervical cancer and a majority of vulvar cancers. Persistent HPV infections must evade host immune responses, including cytokines released by activated T-helper (Th) cells. In this study, we investigated the risk of cervical and vulvar cancer associated with common genetic variations in 560 tagging single-nucleotide polymorphisms (SNPs) in candidate cytokine genes.