Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels.

Publication Type:

Journal Article

Source:

American journal of human genetics, Volume 77, Issue 1, p.64-77 (2005)

Keywords:

Adolescent, Base Sequence, C-Reactive Protein, Female, Gene Frequency, Haplotypes, Humans, Male, Polymorphism, Genetic, Polymorphism, Single Nucleotide, Promoter Regions, Genetic

Abstract:

Elevated plasma levels of C-reactive protein (CRP), an inflammation-sensitive marker, have emerged as an important predictor of future cardiovascular disease and metabolic abnormalities in apparently healthy men and women. Here, we performed a systematic survey of common nucleotide variation across the genomic region encompassing the CRP gene locus. Of the common single-nucleotide polymorphisms (SNPs) identified, several in the CRP promoter region are strongly associated with CRP levels in a large cohort study of cardiovascular risk in European American and African American young adults. We also demonstrate the functional importance of these SNPs in vitro.