Polymorphisms predicted to alter function in prostaglandin E2 synthase and prostaglandin E2 receptors.

Publication Type:

Journal Article

Source:

Pharmacogenetics and genomics, Volume 17, Issue 3, p.221-7 (2007)

Keywords:

African Continental Ancestry Group, Amino Acid Substitution, Base Sequence, European Continental Ancestry Group, Forecasting, Gene Frequency, Humans, Intramolecular Oxidoreductases, Polymorphism, Genetic, Receptors, Prostaglandin E, Sequence Analysis, Protein, Sequence Homology, Amino Acid, Software, Structure-Activity Relationship

Abstract:

Prostaglandin synthesis is the primary target of aspirin and other nonsteroidal antiinflammatory drugs, and thus is a pathway of major interest to pharmacology, pharmacogenetics, and epidemiology. Several lines of evidence implicate prostaglandin E2 in carcinogenesis; this study aimed to identify genetic variants in genes related to prostaglandin E2 synthesis and signaling.