Polymorphisms in oxidative stress and inflammation pathway genes, low-dose ionizing radiation, and the risk of breast cancer among US radiologic technologists.

Publication Type:

Journal Article

Source:

Cancer causes & control : CCC, Volume 21, Issue 11, p.1857-66 (2010)

Keywords:

2010, Allied Health Personnel, Breast Neoplasms, Case-Control Studies, Center-Authored Paper, Chronic Disease, Cohort Studies, Cyclooxygenase 2, Dose-Response Relationship, Radiation, Female, Genotype, Humans, INFLAMMATION, Neoplasms, Radiation-Induced, Occupational Diseases, OXIDATIVE STRESS, Polymorphism, Genetic, Polymorphism, Single Nucleotide, Public Health Sciences Division, Radiation, Ionizing, RISK, Technology, Radiologic

Abstract:

Ionizing radiation, an established breast cancer risk factor, has been shown to induce oxidative damage and chronic inflammation. Polymorphic variation in oxidative stress and inflammatory-mediated pathway genes may modify radiation-related breast cancer risk.