Polymorphisms near TBX5 and GDF7 are associated with increased risk for Barrett's esophagus.

Publication Type:

Journal Article

Authors:

Palles, Claire; Chegwidden, Laura; Li, Xinzhong; Findlay, John M; Farnham, Garry; Castro Giner, Francesc; Peppelenbosch, Maikel P; Kovac, Michal; Adams, Claire L; Prenen, Hans; Briggs, Sarah; Harrison, Rebecca; Sanders, Scott; MacDonald, David; Haigh, Chris; Tucker, Art; Love, Sharon; Nanji, Manoj; de Caestecker, John; Ferry, David; Rathbone, Barrie; Hapeshi, Julie; Barr, Hugh; Moayyedi, Paul; Watson, Peter; Zietek, Barbara; Maroo, Neera; Gay, Laura; Underwood, Tim; Boulter, Lisa; McMurtry, Hugh; Monk, David; Patel, Praful; Ragunath, Krish; Al Dulaimi, David; Murray, Iain; Koss, Konrad; Veitch, Andrew; Trudgill, Nigel; Nwokolo, Chuka; Rembacken, Bjorn; Atherfold, Paul; Green, Elaine; Ang, Yeng; Kuipers, Ernst J; Chow, Wu; Paterson, Stuart; Kadri, Sudarshan; Beales, Ian; Grimley, Charles; Mullins, Paul; Beckett, Conrad; Farrant, Mark; Dixon, Andrew; Kelly, Sean; Johnson, Matthew; Wajed, Shahjehan; Dhar, Anjan; Sawyer, Elinor; Roylance, Rebecca; Onstad, Lynn; Gammon, Marilie D; Corley, Douglas A; Shaheen, Nicholas J; Bird, Nigel C; Hardie, Laura J; Reid, Brian J; Ye, Weimin; Liu, Geoffrey; Romero, Yvonne; Bernstein, Leslie; Wu, Anna H; Casson, Alan G; Fitzgerald, Rebecca; Whiteman, David C; Risch, Harvey A; Levine, David M; Vaughan, Tom L; Verhaar, Auke P; van den Brande, Jan; Toxopeus, Eelke L; Spaander, Manon C; Wijnhoven, Bas P L; van der Laan, Luc J W; Krishnadath, Kausilia; Wijmenga, Cisca; Trynka, Gosia; McManus, Ross; Reynolds, John V; O'Sullivan, Jacintha; MacMathuna, Padraic; McGarrigle, Sarah A; Kelleher, Dermot; Vermeire, Severine; Cleynen, Isabelle; Bisschops, Raf; Tomlinson, Ian; Jankowski, Janusz

Source:

Gastroenterology, Volume 148, Issue 2, p.367-78 (2015)

Keywords:

Barrett Esophagus, Bone Morphogenetic Proteins, Esophageal Neoplasms, Genetic Predisposition to Disease, Genome-Wide Association Study, Growth Differentiation Factors, Humans, Polymorphism, Single Nucleotide, RISK, T-Box Domain Proteins

Abstract:

Barrett's esophagus (BE) increases the risk of esophageal adenocarcinoma (EAC). We found the risk to be BE has been associated with single nucleotide polymorphisms (SNPs) on chromosome 6p21 (within the HLA region) and on 16q23, where the closest protein-coding gene is FOXF1. Subsequently, the Barrett's and Esophageal Adenocarcinoma Consortium (BEACON) identified risk loci for BE and esophageal adenocarcinoma near CRTC1 and BARX1, and within 100 kb of FOXP1. We aimed to identify further SNPs that increased BE risk and to validate previously reported associations.