Pleiotropic effects of genetic risk variants for other cancers on colorectal cancer risk: PAGE, GECCO and CCFR consortia.

Publication Type:

Journal Article


Gut, Volume 63, Issue 5, p.800-7 (2014)


2013, 2014, Center-Authored Paper, Public Health Sciences Division, Scientific Imaging Core Facility, September 2013, Shared Resources, Specimen Processing Core Facility


Genome-wide association studies have identified a large number of single nucleotide polymorphisms (SNPs) associated with a wide array of cancer sites. Several of these variants demonstrate associations with multiple cancers, suggesting pleiotropic effects and shared biological mechanisms across some cancers. We hypothesised that SNPs previously associated with other cancers may additionally be associated with colorectal cancer. In a large-scale study, we examined 171 SNPs previously associated with 18 different cancers for their associations with colorectal cancer.