Plausibility of stromal initiation of epithelial cancers without a mutation in the epithelium: a computer simulation of morphostats.

Publication Type:

Journal Article


BMC cancer, Volume 9, p.89 (2009)


2009, Animals, Cell Communication, Cell Differentiation, Cell Polarity, Cell Transformation, Neoplastic, Center-Authored Paper, Computer Simulation, Epithelial Cells, Humans, Models, Theoretical, MORPHOGENESIS, Mutation, Neoplasms, PHENOTYPE, Public Health Sciences Division, Stromal Cells


There is experimental evidence from animal models favoring the notion that the disruption of interactions between stroma and epithelium plays an important role in the initiation of carcinogenesis. These disrupted interactions are hypothesized to be mediated by molecules, termed morphostats, which diffuse through the tissue to determine cell phenotype and maintain tissue architecture.