Planar cell polarity planes the inconveniences of cell division into a smooth morphogenetic process.

Publication Type:

Journal Article

Source:

Developmental cell, Volume 10, Issue 2, p.153-4 (2006)

Keywords:

Animals, Cell Adhesion, Cell Division, Cell Polarity, MORPHOGENESIS, Mutation, Nervous System, Signal Transduction, zebrafish

Abstract:

Cell divisions are necessary, but also very disruptive for morphogenesis. Dividing cells lose many intercellular contacts and polarized features. This breaks the magnificent topology of the developing embryo and, if left unrepaired, can lead to severe tissue disorganization. A recent study demonstrated that cells use the planar cell polarity pathway to reestablish polarity and reintegrate daughter cells into developing tissue.