Phase III randomized intergroup trial of subtotal lymphoid irradiation versus doxorubicin, vinblastine, and subtotal lymphoid irradiation for stage IA to IIA Hodgkin's disease.

Publication Type:

Journal Article


Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Volume 19, Issue 22, p.4238-44 (2001)


Adolescent, Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols, Combined Modality Therapy, Doxorubicin, Female, Follow-Up Studies, Hodgkin Disease, Humans, Lymphoid Tissue, Male, Middle Aged, Neoplasm Staging, Prospective Studies, Radiotherapy Dosage, Survival Rate, Treatment Outcome, Vinblastine


The management of early-stage Hodgkin's disease in the United States is controversial. To evaluate whether staging laparotomy could be safely avoided in early-stage Hodgkin's disease and whether chemotherapy should be a part of the treatment of nonlaparotomy staged patients, a phase III intergroup trial was performed.