Peripheral-blood stem cells versus bone marrow from unrelated donors.

Publication Type:

Journal Article


The New England journal of medicine, Volume 367, Issue 16, p.1487-96 (2012)


Adult, Bone Marrow Diseases, Bone Marrow Transplantation, Cause of Death, Clinical Research Division, Female, Graft Rejection, Graft vs Host Disease, Histocompatibility Testing, Humans, Intention to Treat Analysis, Kaplan-Meier Estimate, LEUKEMIA, Male, November 2012, Peripheral Blood Stem Cell Transplantation, Proportional Hazards Models, RECURRENCE, Survival Rate, Unrelated Donors


Randomized trials have shown that the transplantation of filgrastim-mobilized peripheral-blood stem cells from HLA-identical siblings accelerates engraftment but increases the risks of acute and chronic graft-versus-host disease (GVHD), as compared with the transplantation of bone marrow. Some studies have also shown that peripheral-blood stem cells are associated with a decreased rate of relapse and improved survival among recipients with high-risk leukemia.