The performance of prostate specific antigen for predicting prostate cancer is maintained after a prior negative prostate biopsy.

Publication Type:

Journal Article


The Journal of urology, Volume 180, Issue 2, p.544-7 (2008)


2008, Aged, Aged, 80 and over, Biopsy, Needle, Confidence Intervals, Digital Rectal Examination, Humans, Immunohistochemistry, Male, Mass Screening, Middle Aged, Predictive Value of Tests, Prognosis, Prostate-Specific Antigen, Prostatic Neoplasms, Public Health Sciences Division, Risk Assessment, ROC Curve, Statistics, Nonparametric, Survival Analysis, Tumor Markers, Biological


It has been suggested that prostate specific antigen has no predictive value for prostate cancer after a first negative biopsy has been performed. We compared the performance operating characteristics of prostate specific antigen for prostate cancer between a first and subsequent prostate biopsy in a group of men with complete verification of cancer status.