Performance of prediction models for BRCA mutation carriage in three racial/ethnic groups: findings from the Northern California Breast Cancer Family Registry.

Publication Type:

Journal Article

Source:

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Volume 18, Issue 4, p.1084-91 (2009)

Keywords:

Adult, African Americans, Aged, Breast Neoplasms, California, Ethnic Groups, European Continental Ancestry Group, Female, Genes, BRCA1, Genes, BRCA2, Hispanic Americans, Humans, Middle Aged, Models, Statistical, Mutation, Prognosis, Registries, Risk Factors

Abstract:

Patients with early-onset breast and/or ovarian cancer frequently wish to know if they inherited a mutation in one of the cancer susceptibility genes, BRCA1 or BRCA2. Accurate carrier prediction models are needed to target costly testing. Two widely used models, BRCAPRO and BOADICEA, were developed using data from non-Hispanic Whites (NHW), but their accuracies have not been evaluated in other racial/ethnic populations.