Pan-colonic field defects are detected by CGH in the colons of UC patients with dysplasia/cancer.

Publication Type:

Journal Article

Source:

Cancer letters, Volume 320, Issue 2, p.180-8 (2012)

Keywords:

Adult, Colitis, Ulcerative, Colon, Colorectal Neoplasms, COMPARATIVE GENOMIC HYBRIDIZATION, DISEASE PROGRESSION, DNA Copy Number Variations, GENOMIC INSTABILITY, Genomics Core Facility, Humans, Middle Aged, Shared Resources

Abstract:

BAC arrays were used to evaluate genomic instability along the colon of patients with ulcerative colitis (UC). Genomic instability increases with disease progression and biopsies more proximal to dysplasia showed increased instability. Pan-colonic field copy number gain or loss involving small (<1Mb) regions were detected in most patients and were particularly apparent in the UC progressor patients who had dysplasia or cancer. Chromosomal copy gains or losses affecting large regions were mainly restricted to dysplastic biopsies. Areas of significant chromosomal losses were detected in the UC progressors on chromosomes 2q36, 3q25, 3p21, 4q34, 4p16.2, 15q22, and 16p13 (p-valueā©½0.04). These results extend our understanding of the dynamic nature of pan-colonic genomic instability in this disease.