p16 mutation spectrum in the premalignant condition Barrett's esophagus.

Publication Type:

Journal Article

Source:

PloS one, Volume 3, Issue 11, p.e3809 (2008)

Keywords:

2008, Adult, Aged, Aged, 80 and over, Barrett Esophagus, Center-Authored Paper, Clone Cells, Cohort Studies, DNA Mutational Analysis, ESOPHAGUS, Exons, Female, Genes, p16, Genomics Core Facility, Human Biology Division, Humans, Male, Middle Aged, Mutation, Precancerous Conditions, Public Health Sciences Division, Shared Resources, Young Adult

Abstract:

Mutation, promoter hypermethylation and loss of heterozygosity involving the tumor suppressor gene p16 (CDKN2a/INK4a) have been detected in a wide variety of human cancers, but much less is known concerning the frequency and spectrum of p16 mutations in premalignant conditions.