Outcomes of acute leukemia patients transplanted with naive T cell-depleted stem cell grafts.

Publication Type:

Journal Article


The Journal of clinical investigation, Volume 125, Issue 7, p.2677-89 (2015)


2015, Flow Cytometry Core Facility, Research Trials Office Core Facility - Biostatistics Service


Graft-versus-host disease (GVHD) is a major cause of morbidity and mortality following allogeneic hematopoietic stem cell transplantation (HCT). In mice, naive T cells (TN) cause more severe GVHD than memory T cells (TM). We hypothesized that selective depletion of TN from human allogeneic peripheral blood stem cell (PBSC) grafts would reduce GVHD and provide sufficient numbers of hematopoietic stem cells and TM to permit hematopoietic engraftment and the transfer of pathogen-specific T cells from donor to recipient, respectively.