Oral chronic graft-versus-host disease: report from the International Consensus Conference on clinical practice in cGVHD.

Publication Type:

Journal Article

Source:

Clinical oral investigations, Volume 15, Issue 2, p.127-39 (2011)

Keywords:

336, Administration, Topical, Center-Authored Paper, Chronic Disease, Clinical Research Division, Consortium Authored Paper, Dental Caries, Evidence-Based Dentistry, Glucocorticoids, Graft vs Host Disease, hematopoietic stem cell transplantation, Humans, Immunosuppressive Agents, Jaw Diseases, Mouth Diseases, Mouth Neoplasms, Neoplasms, Second Primary, Oral Surgical Procedures, Osteonecrosis, Periodontal Diseases, Xerostomia

Abstract:

Chronic graft-versus-host disease (cGVHD) is a multi-organ disease that occurs post-hematopoietic stem cell transplantation, with the mouth being one of the most frequently affected organs. In 2009, the German-Austrian-Swiss working party on bone marrow and blood stem cell transplantation held a consensus conference to define clinical management of cGVHD. The consensus conference aimed to summarize the literature on diagnosis and topical treatment options for oral cGVHD and to provide recommendations for clinical practice, including routine dental and oral care as well as monitoring for secondary malignancies and bisphophonate-induced osteonecrosis of the jaw.